There are many misconceptions around marijuana. On major misconception is that a marijuana overdose can kill you. When people refer to the effects of marijuana, they are primarily referring to the effects of THC. The short answer to this question is that marijuana, or more specifically THC, the active compound, cannot kill you, and this is explained in more detail below How THC Works THC works by acting on the endocannabinoid system. The endocannabinoid system…"Can Marijuana Overdose Kill You?"